서울대학교 약학대학 약학과, 약학사
KAIST 생물공학, 이학석사
KAIST 생물공학, 이학박사

한국생명공학연구원 객원선임연구원
KAIST 의과학연구센터 연구원
서울대학교 의과대학 핵의학과 BK21계약교수
한국원자력의학원 방사선의학연구소 책임연구원
한국원자력의학원 방사선의학연구소 분자영상연구부 부장
한국원자력의학원 방사선의학연구소 소장
한국원자력의학원 국가RI신약센터 센터장

방사성의약품 개발, 생체 분자영상 기술, 질환모델 개발, 신약 유효성/ADME 평가

Feasibility Study of Single-Photon Emission Computed Tomography with Iodine-123 Labeled Metaiodobenzylguanidine for Preclinical Evaluation of Labetalol as a β-Adrenergic Receptor Blocker. Mol Pharm. 2024;21(5):2435-2440

Therapeutic Response Monitoring with 89Zr-DFO-Pertuzumab in HER2-Positive and Trastuzumab-Resistant Breast Cancer Models. Pharmaceutics. 2022;14(7):1338

A microdose clinical trial to evaluate [18F]Florastamin as a positron emission tomography imaging agent in patients with prostate cancer. Eur J Nucl Med Mol Imaging. 2021;48(1):95-102

A preliminary clinical trial to evaluate 64Cu-NOTA-Trastuzumab as a positron emission tomography imaging agent in patients with breast cancer EJNMMI Res. 2021;11(1):8.

Development of a Theranostic Convergence Bioradiopharmaceutical for Immuno-PET Based Radioimmunotherapy of L1CAM in Cholangiocarcinoma Model. Clin Cancer Res. 2019;25(20):6148-6159


Development of 64Cu-NOTA-Trastuzumab for HER2 Targeting: A Radiopharmaceutical with Improved Pharmacokinetics for Human Studies. J Nucl Med. 2019;60(1):26-33.

PET Imaging Biomarkers of Anti-EGFR Immunotherapy in Esophageal Squamous Cell Carcinoma Models. Cells. 2018;7(11):187

Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer. Neuropharmacology. 2018;133:512-517.

Immuno-PET imaging based radioimmunotherapy in head and neck squamous cell carcinoma model. Oncotarget. 2017;8(54):92090-92105.

Monitoring of macrophage accumulation in statin-treated atherosclerotic mouse model using sodium iodide symporter imaging system. Nucl Med Biol. 2017:48:45-51

Radioimmunotherapy with (131)I-rituximab as consolidation therapy for patients with diffuse large B-cell lymphoma. Cancer Chemother Pharmacol. 2016;78(4):825-31

Immuno-PET Imaging and Radioimmunotherapy of 64Cu-/177Lu-Labeled Anti-EGFR Antibody in Esophageal Squamous Cell Carcinoma Model. J Nucl Med. 2016;57(7):1105-11

Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma. World J Gastroenterol. 2016;22(27):6127-34.

Detection of metastatic tumors after γ-irradiation using longitudinal molecular imaging and gene expression profiling of metastatic tumor nodules. Int J Oncol. 2016;48(4):1361-8

Evaluation of safety and efficacy of adipose-derived stem cells in rat myocardial infarction model using hexadecyl-4-[¹²⁴I]iodobenzoate for cell tracking. Appl Radiat Isot. 2016;108:116-123.

Adenovirus-mediated expression of human sodium-iodide symporter gene permits in vivo tracking of adipose tissue-derived stem cells in a canine myocardial infarction model. Nucl Med Biol. 2015;42(7):621-9.

Simple Methods for Tracking Stem Cells with (64)Cu-Labeled DOTA-hexadecyl-benzoate. ACS Med Chem Lett. 2015;6(5):528-30

Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4. Oncotarget 2015:6(12) 9820-9833

γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages. J Leukocyte Biology. 2015:97 711-721

Evaluation of a 64Cu-labeled 1,4,7-triazacyclononane, 1-glutaric acid-4,7 acetic acid (NODAGA)-galactose-bombesin analogue as a PET imaging probe in a gastrin-releasing peptide receptor-expressing prostate cancer xenograft model. International Journal of Oncology, 2015:46(3)1159-1168

Longitudinal monitoring by in vivo PET imaging of adipose-derived stem cell survival using hexadecyl-4-124I-iodobenzoate in rat myocardial infarction model. Biochem Biophys Res Commun 2015; 456(1): 13-19

Assessment of α-Fetoprotein Targeted HSV1-tk Expression in Hepatocellular Carcinoma with In Vivo Imaging. Cancer Biother Radiopharm 2015:30(1):8-15

Evaluation of diethylnitrosamine- or hepatitis B virus X gene-induced hepatocellular carcinoma with 18F-FDG PET/CT: A preclinical study, Oncology Reports 2015:33(1):347-353

Effect of Harderian adenectomy on the statistical analyses of mouse brain imaging using positron emission tomography J Vet Sci. 2014;15(1):157-61.

Detection of Increased 64Cu Uptake by Human Copper Transporter 1 Gene Overexpression Using PET with 64CuCl2 in Human Breast Cancer Xenograft Model. J Nucl Med. 2014;55(10):1692-8.

Performance measurement of PSF modeling reconstruction (True X) on Siemens Biograph TruePoint TrueV PET/CT. Ann Nucl Med. 2014;28:340-8.

Synthesis and Evaluation of a 18F-Labeled 4-Ipomeanol as an Imaging Agent for CYP4B1 Gene Prodrug Activation Therapy. Cancer Biother Radiopharm. 2013;28(8):588-597

Assessment of early phase F18-FP-CIT PET as an alternative method of FDG PET for voxel based statistical analysis: Application for Parkinson’s disease rat model IEEE TRANSACTIONS ON NUCLEAR SCIENCE 2013;60(2):820-823

RGD Peptide-Conjugated Multimodal NaGdF4:Yb3+/Er3+ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis. J Nucl Med. 2013;54(1):96-103

Comparison of Cell-Labeling Methods with (124)I-FIAU and (64)Cu-PTSM for Cell Tracking Using Chronic Myelogenous Leukemia Cells Expressing HSV1-tk and Firefly Luciferase. Cancer Biother Radiopharm. 2012;27(10):719-28.

Establishment of animal model for the analysis of cancer cell metastasis during radiotherapy. Radiat Oncol. 2012;7(1):153-163

In vivo bioluminescent imaging of α-fetoprotein-producing hepatocellular carcinoma in the diethylnitrosamine-treated mouse using recombinant adenoviral vector. J Gene Med. 2012;14(8):513-20.

Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides. Int J Med Microbiol. 2012;302(2):101-7

Complementary treatment of siTERT for improving the antitumor effect of TERT-specific I-131 therapy. Cancer Gene Ther. 2012.19:263-270

Gamma camera and optical imaging with a fusion reporter gene using human sodium/iodide symporter and monomeric red fluorescent protein in mouse model. Int J Radiat Biol. 2011;87(12):1182-8.

Non-invasive monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging. Cancer Lett. 2011;310(1):53-60.

Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent. Appl Radiat Isot. 2011;69(1):56-62

Actin-sequestering protein, thymosin beta-4, is a novel hypoxia responsive regulator. Clin Exp Metastasis. 2010;27(8):601-9.

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma. Cancer Lett. 2010;297(1):84-90

Wild-type p53 enhances the cytotoxic effect of radionuclide gene therapy using sodium iodide symporter in a murine anaplastic thyroid cancer model. Eur J Nucl Med Mol Imaging. 2010;37(2):235-41

Comparison of 18F-FDG, 18F-FET and 18F-FLT for differentiation between tumor and inflammation in rats. Nuclear Medicine and Biology. 2009:36, 681-686

Radioiodine gene therapy of hepatocellular carcinoma targeted human alpha fetoprotein. Cancer Biother Radiopharm. 2008;23(5):551-60

Tumor targeted radionuclide imaging and therapy using human sodium iodide symporter gene driven by a modified telomerase reverse transcriptase promoter. Hum Gene Ther. 2008;19(9):951-7

Visualization of Hypoxia-Inducible Factor-1 Transcriptional Activation in C6 Glioma Using Luciferase and Sodium Iodide Symporter Genes. J Nucl Med. 2008;49(9):1489-97.

Anesthesia condition for (18)F-FDG imaging of lung metastasis tumors using small animal PET. Nucl Med Biol. 2008;35(1):143-50

Molecular-Genetic Imaging Based on Reporter Gene Expression. J Nucl Med 2008; 49:164S-179S

Noninvasive in vivo monitoring of neuronal differentiation using reporter driven by a neuronal promoter. Eur J Nucl Med Mol Imaging 2008; 35(1): 135-145.

In vivo bioluminescence visualization of antitumor effects by human MUC1 vaccination. Mol Imaging 2007; 6(5): 297-303.

Doxorubicin enhances the expression of transgene under control of the CMV promoter in anaplastic thyroid carcinoma cells. J Nucl Med. 2007;48(9):1553-61

In Vivo Long-Term Imaging and Radioiodine Therapy by Sodium-Iodide Symporter Gene Expression Using a Lentiviral System Containing Ubiquitin C Promoter. Cancer Biol Ther 2007;6(7):1130-1135

Development of a dual membrane protein reporter system using sodium iodide symporter and mutant dopamine D2 receptor transgenes. J Nucl Med. 2007;48(4):588-95

MIDGE/hNIS vaccination generates antigen-associated CD8+ IFN-Υ+ T cells and enhances protective antitumor immunity.International Journal of Cancer 2007;120(9):1942-50

An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK) Nucl Med Biol. 2006;33(5):677-83(2006)


Evaluation of transcriptional activity of the oestrogen receptor with sodium iodide symporter as an imaging reporter gene. Nucl Med Commun. 2006;27(10):773-7

A new hepatocytic isoform of PLZF lacking the BTB domain interacts with ATP7B, the Wilson disease protein, and positively regulates ERK signal transduction. J Cell Biochem 2006;99,719-734

In vivo monitoring of DNA vaccine gene expression using firefly luciferase as a naked DNA. Vaccine 2006;24(16):3057-3062

In vivo Imaging of Adenovirus Transduction and Enhanced Therapeutic Efficacy of Combination Therapy with Conditionally Replicating Adenovirus and Adenovirus-p27 Cancer Research 2006;66(1):372-377

Development of a sodium/iodide symporter (NIS)-transgenic mouse for imaging of cardiomyocyte-specific reporter gene expression. J Nucl Med. 2005;46:479-83

Reversing the silencing of reporter sodium/iodide symporter transgene for stem cell tracking. J Nucl Med. 2005;46:305-11

Visualization of endogenous p53-mediated transcription in vivo using sodium iodide symporter. Clin Cancer Res. 2005;11:123-8

In vitro and in vivo properties of a human anaplastic thyroid carcinoma cell line transfected with the sodium iodide symporter gene. Thyroid. 2004;14:889-95

Development of 99mTc-neomannosyl human serum albumin (99mTc-MSA) as a novel receptor binding agent for sentinel lymph node imaging. Nucl Med Commun. 2004;25:1211-7

Noninvasive imaging for monitoring of viable cancer cells using a dual-imaging reporter gene. J Nucl Med. 2004;45:2109-15

Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy. J Nucl Med. 2004;45:1571-6

Translational research using the sodium/iodide symporter in imaging and therapy. Eur J Nucl Med Mol Imaging. 2004;31:799-802

Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk. Eur J Nucl Med Mol Imaging. 2004;31:425-32